化工社化工社 化学情報印刷レポート · 研究参考用
hydrogen chloride CPME → N-[4-(trans-2-aminocyclopropyl)-2-methylphenyl]benzamide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | hydrogen chloride CPME | HCID 66926893 | — |
| 反応物 | tert-Butyl {trans-2-[4-(benzoylamino)-3-methylphenyl]cyclopropyl}carbamate | HCID 86729917 | — |
| 生成物 | N-[4-(trans-2-aminocyclopropyl)-2-methylphenyl]benzamide hydrochloride | HCID 86729915 | — |
反応手順
tert-Butyl {trans-2-[4-(benzoylamino)-3-methylphenyl]cyclopropyl}carbamate (125.8 mg) was dissolved in 4N hydrochloric acid/cyclopentyl methyl ether solution (1.5 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give the title compound (95.9 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09278931B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-b95ec5a89708440e9cc9ff1fdf103d08 |
| 出典メモ | uspto-grants-2016_03 |