hydrogen chloride CPME → HCID 86729923, compound

HRID 922552Notes

Reaction equation

HRID 922552 reaction equation
C(OC(=O)[N:7]([CH2:27][CH:28]1[CH2:30][CH2:29]1)[C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]2=[O:26])=[CH:13][CH:12]=1)(C)(C)C.[ClH:32].COC1CCCC1>>[ClH:32].[CH:28]1([CH2:27][NH:7][C@@H:8]2[CH2:10][C@H:9]2[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:25][C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[C:18]3=[O:26])=[CH:13][CH:12]=2)[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 66926893hydrogen chloride CPMEHCID 86729925HCID 86729925, compound

Product 1

HCID 86729923HCID 86729923, compound

Procedure

tert-Butyl(cyclopropylmethyl){trans-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]cyclopropyl}carbamate (123.7 mg) was dissolved in 4N hydrochloric acid/cyclopentyl methyl ether solution (1.5 mL), and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated under reduced pressure. The residue was recrystallized from methanol/diisopropyl ether to give the title compound (76.4 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from methanol/diisopropyl ether

Sources & evidence

ORD record
ord-79b8d6f7ee404aea8b2922ded0ec4be2
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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