Hydrogen chloride-ethyl acetate → HCID 86729926, compound

HRID 922553Notes

Reaction equation

HRID 922553 reaction equation
C(OC(=O)[N:7]([CH2:30][CH:31]1[CH2:33][CH2:32]1)[C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:29])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([S:25](=[O:28])(=[O:27])[NH2:26])[CH:20]=2)=[CH:13][CH:12]=1)(C)(C)C.[ClH:35].C(OCC)(=O)C>>[ClH:35].[CH:31]1([CH2:30][NH:7][C@@H:8]2[CH2:10][C@H:9]2[C:11]2[CH:12]=[CH:13][C:14]([NH:17][C:18](=[O:29])[C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([S:25](=[O:27])(=[O:28])[NH2:26])[CH:20]=3)=[CH:15][CH:16]=2)[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86729928HCID 86729928, compound

Product 1

HCID 86729926HCID 86729926, compound

Procedure

tert-Butyl(cyclopropylmethyl)(trans-2-{4-[(3-sulfamoylbenzoyl)amino]phenyl}cyclopropyl)carbamate (125.0 mg) was dissolved in 4N hydrochloric acid/ethyl acetate solution (1.25 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure. The residue was recrystallized from methanol/diisopropyl ether to give the title compound (69.5 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from methanol/diisopropyl ether

Sources & evidence

ORD record
ord-44993dd38ef64fdfbe18663b396151bd
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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