hydrogen chloride CPME → T-3775440 hydrochloride

HRID 922556Notes

Reaction equation

HRID 922556 reaction equation
C(OC(=O)[N:7]([CH2:26][CH:27]1[CH2:29][CH2:28]1)[C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]2[CH:21]=[N:22][N:23]([CH3:25])[CH:24]=2)=[O:19])=[CH:13][CH:12]=1)(C)(C)C.[ClH:31].COC1CCCC1>>[ClH:31].[CH:27]1([CH2:26][NH:7][C@@H:8]2[CH2:10][C@H:9]2[C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]3[CH:21]=[N:22][N:23]([CH3:25])[CH:24]=3)=[O:19])=[CH:13][CH:12]=2)[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 66926893hydrogen chloride CPMEHCID 86729931tert-butyl (cyclopropylmethyl)[trans-2-(4-{[(1-methyl-1H-pyrazol-4-yl)carbonyl]amino}phenyl)cyclopropyl]carbamate

Product 1

HCID 86729932T-3775440 hydrochloride

Procedure

tert-Butyl(cyclopropylmethyl)[trans-2-(4-{[(1-methyl-1H-pyrazol-4-yl)carbonyl]amino}phenyl)cyclopropyl]carbamate (114.8 mg) was dissolved in 4N hydrochloric acid/cyclopentyl methyl ether solution (1 mL), and the mixture was stirred at room temperature for 1.5 hr. The solvent was evaporated under reduced pressure. The residue was recrystallized from methanol/diisopropyl ether to give the title compound (51.1 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from methanol/diisopropyl ether

Sources & evidence

ORD record
ord-8eec101a7a5f40edb1b0550695364138
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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