HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → HCID 117696650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 2-(4-Hydroxyphenyl)propionic acid | HCID 102526 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 117696650 | HCID 117696650 | — |
Reaction Steps
To 4.00 g (24.1 mmol) 2-(4-hydroxyphenyl)propionic acid in 50 mL THF and 5 ml DMF are added 6.76 g (66.1 mmol) TEA and 8.50 g TBTU. The reaction mixture is stirred at r.t. for 5 min, then 36.1 ml (2 mold solution; 72.2 mmol) ethylamine are added. The reaction mixture is stirred at r.t. 5 h. The solvent is removed in vacuo and the crude product is purified by prep. HPLC-MS (ACN/H2O/NH4OH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278954B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-91f8d8bfa63e4372b6feedff920881b9 |
| Source note | uspto-grants-2016_03 |