HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (S)-1-Boc-3-methanesulfonyloxy-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate | HCID 854055 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (S)-1-Boc-3-methanesulfonyloxy-pyrrolidine | HCID 11032777 | — |
Reaction Steps
To 3.44 g (187 mmol) (S)-1-Boc-3-pyrrolidinol in 15 ml THF are added 1.70 mL (21.6 mmol) of methanesulfonyl chloride at 0° C. The reaction mixture is stirred for 1 h. Water is added and it is extracted with EtOAc (3×). The organic layer is washed with an aq. NaHCO3 solution and dried over MgSO4. The solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278954B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-0a090a72c35e45f3a1fae04bdafe52a4 |
| Source note | uspto-grants-2016_03 |