HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 922561Generated: November 1, 2026
4-Bromophenol → 1-Bromo-4-(cyclobutyloxy)benzene
https://huagongshe.com/reaction/922561
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bromocyclobutane | HCID 78110 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Bromo-4-(cyclobutyloxy)benzene | HCID 67987998 | — |
Reaction Steps
The mixture of 2.50 g (14.5 mmol) of 4-bromophenol, 2.04 ml (21.7 mmol) of cyclobutyl bromide and 7.99 g (57.8 mmol) of K2CO3 in 25 ml DMF is stirred at 120° C. over night. The reaction mixture is extracted with water and EtOAc. The organic layer is dried, filtered and the solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09278954B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-b2861fa63ec54c5ea13073049c443bb2 |
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| Source note | uspto-grants-2016_03 |
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