Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Bromomethyl)cyclobutane | HCID 2734658 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 65457361 | HCID 65457361 | — |
Reaction Steps
The mixture of 2.50 g (14.5 mmol) of 4-bromophenol, 2.44 ml (21.7 mmol) of bromomethylcyclobutane and 7.99 g (57.8 mmol) of K2CO3 in 3 ml DMF is stirred at 100° C. over night. The reaction mixture is extracted with water and EtOAc. The organic layer is dried, filtered and the solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09278954B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-83f691da8436468f89277d46ad4ea034 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
