Potassium Hydroxide → HCID 86719690, compound

Participants

Reaction Conditions

Reaction Steps

4,5-Dichloroimidazole (1.37 g, 10.0 mmol) and potassium hydroxide (0.61 g, 11.0 mmol) were placed in a round bottom flask and 10 mL acetonitrile was added. The mixture was refluxed for 30 min. The flask was removed from the head and 2-(bromomethyl)naphthalene (2.21, 10.0 mmol) was added. The mixture was returned to heat and refluxed for 2.5 h, during which time a white precipitate formed. The mixture was filtered hot, and upon cooling a precipitate formed in the filtrate. The solid, the mono-substituted imidazole, was collected by a second filtration. This solid (0.28 g, 1.0 mmol) and 2-(bromomethyl)anthraquinone (0.90 g, 3.0 mmol) will be placed in a high-pressure vessel and dissolved in the minimum volume of DMF. The solution will be heated to 100° C. for 8 h. Removal of the volatile components under reduced pressure will yield the product.

Provenance & Evidence