Potassium Hydroxide → 1,3-Bis(quinoxalin-2-ylmethyl)-4,5-dichloroimidazolium bromide

Participants

Reaction Steps

4,5-dichloroimidazole (1.37 g, 10 mmol) will be dissolved in a minimum amount of acetonitrile and potassium hydroxide (0.62 g, 11 mmol) will be added. The mixture will be stirred at reflux until the potassium hydroxide is consumed, approximately 30 min. 2-(Bromomethyl)quinoxaline (2.23 g, 10.0 mmol) will be added and the mixture will be returned to reflux for 3 h. The mixture will be filtered hot to remove the potassium bromide generated. A second addition of 2-(bromomethyl)quinoxaline (2.23 g, 10.0 mmol) will be made to the reaction solution, which will be returned to reflux for 6 h. Removal of the volatile components under reduced pressure should yield the product.

Provenance & Evidence