Potassium Hydroxide → HCID 86719736, compound

HRID 922687Notes

Reaction equation

HRID 922687 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[Cl:7].[OH-:8].[K+].[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17]>C(#N)C>[Br-:10].[C:16]([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][N:3]1[C:2]([Cl:1])=[C:6]([Cl:7])[N+:5]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:17])=[O:8])=[CH:4]1)([OH:18])=[O:17]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 202106-Bromohexanoic acidHCID 1400184,5-Dichloroimidazole

Product 1

HCID 86719736HCID 86719736, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4,5-dichloroimidazole (1.00 g, 7.36 mmol) was dissolved in acetonitrile. Potassium hydroxide (0.828 g, 14.72 mmol) was added to the solution and allowed to reflux for 30 min. 2 equivalents of 6-bromohexanoic acid (2.87 g, 14.72 mmol) was added to the solution and refluxed for 5 h. Solution was filtered to remove the KBr precipitate and neutralized with 6M HBr. Volatiles were removed in vacuo and the resulting product will be collected and analyzed.

Workup

  1. temperatureto reflux for 30 min
  2. temperaturerefluxed for 5 h
  3. filtrationSolution was filtered
  4. customto remove the KBr precipitate
  5. customVolatiles were removed in vacuo
  6. customthe resulting product will be collected

Sources & evidence

ORD record
ord-e55562bfb71b42eaaa5254818ff650d4
Source dataset
uspto-grants-2016_03
Patent number
US09278951B2

Reaction notes

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