1-Methylimidazole → HCID 131734984, compound

Participants

Reaction Steps

In 1 ml of toluene, 50 mg of Compound 8a-1 synthesized in Production Example 19 was dissolved. To the solution thus obtained, 39.5 μl of triethylamine, 22.2 μl of N-methylimidazole, and 53.6 mg of p-toluenesulfonyl chloride were added, and the resulting mixture was stirred at room temperature for 1.5 hours. After the reaction, water was added to the reaction solution thus obtained, and extraction with ethyl acetate was then carried out. The organic layer thus extracted was washed with an aqueous solution of hydrochloric acid, an aqueous solution of sodium hydrogen carbonate, and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled away, and the residue was then purified by silica gel column chromatography to obtain 77.0 mg of Compound 9a-1-2.

Provenance & Evidence