3,3-Difluoropyrrolidine → N-{2-[3-(3,3-difluoropyrrolidin-1-yl)propyl]-3-methylimidazo[1,2-a]pyridin-6-yl}-4-(pyridin-2-ylmethoxy)benzamide
Reaction equation
[F:32][C:33]1([F:38])[CH2:34][NH:35][CH2:36][CH2:37]1.[OH:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]2[n:8]([cH:9][c:10]([NH:13][C:14]([c:15]3[cH:16][cH:17][c:18]([O:21][CH2:22][c:23]4[n:24][cH:25][cH:26][cH:27][cH:28]4)[cH:19][cH:20]3)=[O:29])[cH:11][cH:12]2)[c:30]1[CH3:31]>>[CH2:2]([CH2:3][CH2:4][c:5]1[n:6][c:7]2[n:8]([cH:9][c:10]([NH:13][C:14]([c:15]3[cH:16][cH:17][c:18]([O:21][CH2:22][c:23]4[n:24][cH:25][cH:26][cH:27][cH:28]4)[cH:19][cH:20]3)=[O:29])[cH:11][cH:12]2)[c:30]1[CH3:31])[N:35]1[CH2:34][C:33]([F:32])([F:38])[CH2:37][CH2:36]1Participants
3
Sources & evidence
- ORD record
- ord-df8c1ef40f0145c9938d5dcb7172e0ad
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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