反应详情

温度

60 °C

7-Chloro-4-(2-fluoro-4-methoxyphenyl)quinoline-2-carbonitrile (4.4 g, 14.07 mmol) was suspended in MeOH (70.3 ml), added 200 ml sat HCl/MeOH and then heated to 60° C. for 4 hours. The reaction was allowed to cool to ambient temperature and then was concentrated. The residue was dissolved in EtOAc and then washed with 1:1 1N NaOH/sat NaHCO3, brine, dried (MgSO4) and concentrated to afford methyl 7-chloro-4-(2-fluoro-4-methoxyphenyl)quinoline-2-carboxylate (4.4 g, 12.73 mmol, 90% yield) as a yellow solid.

1. additionadded 200 ml
2. temperatureto cool to ambient temperature
3. concentrationwas concentrated
4. dissolutionThe residue was dissolved in EtOAc
5. washwashed with 1:1 1N NaOH/
6. dry with materialdried (MgSO4)
7. concentrationconcentrated