反应详情

温度

60 °C

A stirred solution of methyl 7-[2-(6-cyanopyridin-3-yl)ethyl]-4-(2-fluoro-4-methoxyphenyl)quinoline-2-carboxylate (160 mg, 0.362 mmol) and MeOH (1450 μl) was treated with 5 ml 7N NH3/MeOH and then heated to 60° C. in a sealed tube for 30 minutes. The reaction was allowed to cool to ambient temperature and then was concentrated. The solid was trituated with EtOH, collected, washed with 5 ml Et2O and then dried in vacuo to afford 7-[2-(6-cyanopyridin-3-yl)ethyl]-4-(2-fluoro-4-methoxyphenyl)quinoline-2-carboxamide (105 mg, 0.246 mmol, 67.9% yield) as a colorless solid.

1. temperatureto cool to ambient temperature
2. concentrationwas concentrated
3. customcollected
4. washwashed with 5 ml Et2O
5. customdried in vacuo