HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 3,5-dimethyl-N-(4-chloro-3-iodophenyl)isoxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 3,5-Dimethylisoxazole-4-carboxylic acid | HCID 75636 | — |
| Reactant | 4-Chloro-3-iodoaniline | HCID 21874954 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 3,5-dimethyl-N-(4-chloro-3-iodophenyl)isoxazole-4-carboxamide | HCID 66878038 | — |
Reaction Steps
4-Chloro-3-iodoaniline (1.01 g, 4 mmol) was used in procedure E with 3,5-dimethyl-4-isoxazolecarboxylic acid (0.565 g, 4 mmol), EDC (1.32 g, 6.8 mmol), TEA (0.5 mL), DMAP (50 mg, 0.4 mmol) at 23° C. for overnight. The crude reaction was purified by silica gel chromatography (0-15% ethyl acetate/CH2Cl2) to yield 3,5-dimethyl-N-(4-chloro-3-iodophenyl)isoxazole-4-carboxamide as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278961B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-b13131070b584a68b6f769b7515e98c0 |
| Source note | uspto-grants-2016_03 |