2,6-Dichloronicotinic acid → HCID 58614627, compound

HRID 922863Notes

Reaction equation

HRID 922863 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[Cl:15][C:16]1[N:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19]>>[Cl:15][C:16]1[C:17]([C:18]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([Cl:1])=[C:3]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=3)[CH:4]=2)=[O:19])=[CH:21][CH:22]=[C:23]([Cl:25])[N:24]=1

Participants

3

Reactant 2

HCID 8540472,6-Dichloronicotinic acidHCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 58614627HCID 58614627, compound

Procedure

Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 2,6-dichloronicotinic acid to produce 2,6-dichloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide. MS (Q1) 378.1 (M)+.

Sources & evidence

ORD record
ord-4a28245fe2264d4c961bc74762f3afec
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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