2-Fluoronicotinic acid → HCID 58614707, compound

HRID 922865Notes

Reaction equation

HRID 922865 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[F:15][C:16]1[N:24]=[CH:23][CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:18]([C:17]2[C:16]([F:15])=[N:24][CH:23]=[CH:22][CH:21]=2)=[O:19])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 960892-Fluoronicotinic acidHCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 58614707HCID 58614707, compound

Procedure

Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 2-fluoronicotinic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-fluoropyridine-3-carboxamide. MS (Q1) 328.1 (M)+.

Sources & evidence

ORD record
ord-d80683c3facf4021927f89f61574c9d8
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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