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HRID922884

反应详情

EQUATION

反应方程式

HRID 922884 的结构方程式

REACTANTS

反应物

2
结构：CCc1ccnc(Br)c1
HCID4114248

2-Bromo-4-ethylpyridine

C7H8BrN

结构：Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(B2OC(C)(C)C(C)(C)O2)c1
HCID66896658

未命名化合物

PRODUCTS

生成物

1
结构：CCc1ccnc(-c2cc(NC(=O)c3ccc(C(F)(F)F)nc3C)ccc2Cl)c1
HCID58614779

未命名化合物

PROCEDURE

实验过程

N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (˜1 mmol) was used in Procedure A with 4-ethyl-2-bromopyridine (1 mmol). Purified by silica gel chromatography (0-60% ethyl acetate/hexanes) to yield N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a tan solid: MS (Q1) 419 (M)+.

WORKUP

后处理

  1. customPurified by silica gel chromatography (0-60% ethyl acetate/hexanes)