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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 922889Generated: October 30, 2026

6-Methoxy-3-pyridinylamine → N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(6-methoxypyridin-3-yl)terephthalamide

https://huagongshe.com/reaction/922889

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Methoxy-3-pyridinylamineHCID 81121—
Reactant4-(4-Chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acidHCID 66877887—
ProductN1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(6-methoxypyridin-3-yl)terephthalamideHCID 58614809—

Reaction Steps

50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2-methoxy-5-aminopyridine via Procedure G. The product was purified on reverse phase HPLC to yield N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(6-methoxypyridin-3-yl)terephthalamide. MS (Q1) 459 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09278961B2
Source datasetuspto-grants-2016_03
ORD IDord-3d95fb8afe3b4f85b4db5000cd9063ad
Source noteuspto-grants-2016_03