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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 922890Generated: October 25, 2026

2,5-Pyridinediamine → N1-(6-aminopyridin-3-yl)-N4-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide

https://huagongshe.com/reaction/922890

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-PyridinediamineHCID 20314—
Reactant4-(4-Chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acidHCID 66877887—
ProductN1-(6-aminopyridin-3-yl)-N4-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamideHCID 58614682—

Reaction Steps

50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2,5-diaminopyridine via Procedure G. The product was purified on reverse phase HPLC to yield N1-(6-aminopyridin-3-yl)-N4-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 444 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09278961B2
Source datasetuspto-grants-2016_03
ORD IDord-93e6f0b9296648cc99830387cc813141
Source noteuspto-grants-2016_03