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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 922959Generated: October 31, 2026

Tert-Butylamine → HCID 10632805, compound

https://huagongshe.com/reaction/922959

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-ButylamineHCID 6385—
Reactant5-(Methoxycarbonyl)pyridine-2-carboxylic acidHCID 314992—
ReactantHCID 15185413HCID 15185413—
ProductHCID 10632805HCID 10632805—

Reaction Steps

250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to tert-butylamine via Procedure G. Crude methyl 6-(tert-butylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 250 mg of 6-(tert-butylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(tert-butylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N2-tert-butyl-N5-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5-dicarboxamide. MS (Q1) 409 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09278961B2
Source datasetuspto-grants-2016_03
ORD IDord-e4ecb6b916d64ff08a707c428d57b998
Source noteuspto-grants-2016_03