HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Pyridinediamine → N4-(6-aminopyridin-3-yl)-2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Pyridinediamine | HCID 20314 | — |
| Reactant | 3-Chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid | HCID 66878605 | — |
| Product | N4-(6-aminopyridin-3-yl)-2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide | HCID 58614771 | — |
Reaction Steps
50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to pyridine-2,5-diamine via Procedure G. The crude product was purified on reverse phase HPLC to yield N4-(6-aminopyridin-3-yl)-2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 478 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278961B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-a4c90e4bd32e46afa92e46c4d2203352 |
| Source note | uspto-grants-2016_03 |