HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethyl-1H-pyrazol-5-amine → 2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(1,3-dimethyl-1H-pyrazol-5-yl)terephthalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethyl-1H-pyrazol-5-amine | HCID 520721 | — |
| Reactant | 3-Chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid | HCID 66878605 | — |
| Product | 2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(1,3-dimethyl-1H-pyrazol-5-yl)terephthalamide | HCID 58614634 | — |
Reaction Steps
50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1,3-dimethyl-1H-pyrazol-5-amine via Procedure G. The crude product was purified on reverse phase HPLC to yield 2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(1,3-dimethyl-1H-pyrazol-5-yl)terephthalamide. MS (Q1) 480 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278961B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-dd438a0099ee41ea93dec3bce1e032cf |
| Source note | uspto-grants-2016_03 |