4-Chloro-3-(pyridin-2-yl)aniline → HCID 58614705, compound

HRID 922983Notes

Reaction equation

HRID 922983 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[N:15]1([CH2:20][CH2:21][N:22]([C:27]2[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[C:29]([Cl:36])[CH:28]=2)[S:23]([CH3:26])(=[O:25])=[O:24])[CH:19]=[CH:18][CH:17]=[CH:16]1>>[N:15]1([CH2:20][CH2:21][N:22]([C:27]2[CH:35]=[CH:34][C:30]([C:31]([NH:6][C:5]3[CH:7]=[CH:8][C:2]([Cl:1])=[C:3]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=4)[CH:4]=3)=[O:32])=[C:29]([Cl:36])[CH:28]=2)[S:23]([CH3:26])(=[O:25])=[O:24])[CH:19]=[CH:18][CH:17]=[CH:16]1

Participants

3

Reactant 2

HCID 401519254-Chloro-3-(pyridin-2-yl)anilineHCID 66896642HCID 66896642, compound

Product 1

HCID 58614705HCID 58614705, compound

Procedure

64 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(N-(2-(1H-pyrrol-1-yl)ethyl)methylsulfonamido)-2-chlorobenzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 4-(N-(2-(1H-pyrrol-1-yl)ethyl)methylsulfonamido)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 529 (M)+.

Workup

  1. customThe crude product was purified by reverse phase HPLC

Sources & evidence

ORD record
ord-a0df4ab215ab4119919f064d6ec49924
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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