HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-(pyridin-2-yl)aniline → N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-(pyridin-2-yl)aniline | HCID 40151925 | — |
| Reactant | 4-((4-methyl-4H-1,2,4-triazol-3-ylsulfinyl)methyl)benzoic acid | HCID 66895591 | — |
| Reactant | 4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzoic acid | HCID 66896168 | — |
| Product | N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzamide | HCID 58614821 | — |
Reaction Steps
114 mg of the mixture of 4-((4-methyl-4H-1,2,4-triazol-3-ylsulfinyl)methyl)benzoic acid and 4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzoic acid was coupled to 75 mg of 4-chloro-3-(pyridin-2-yl)aniline via Procedure G. The mixture was separated on reverse phase HPLC to give N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzamide. MS (Q1) 468.1 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278961B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-e7e61944adf24aa3931d6e384b1ea8c3 |
| Source note | uspto-grants-2016_03 |