Methylamine hydrochloride → HCID 58614915, compound

HRID 923014Notes

Reaction equation

HRID 923014 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:21])[C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[N:12][C:11]=2[CH3:20])=[CH:4][C:3]=1[C:22]1[CH:30]=[CH:29][C:25]([C:26]([O-])=[O:27])=[CH:24][N:23]=1.ClC1C=C[C:35]([NH:38]C(=O)C2C=CC(C(F)(F)F)=NC=2C)=CC=1C1C=CC(C(O)=O)=CN=1.Cl.CN>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:21])[C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:18])([F:19])[F:17])=[N:12][C:11]=2[CH3:20])=[CH:4][C:3]=1[C:22]1[CH:30]=[CH:29][C:25]([C:26](=[O:27])[NH:38][CH3:35])=[CH:24][N:23]=1

Participants

4

Reactant 3

HCID 6364545Methylamine hydrochlorideHCID 66877818HCID 66877818, compoundHCID 86603991HCID 86603991, compound

Product 1

HCID 58614915HCID 58614915, compound

Procedure

120 mg of 6-(2-chloro-5-(2-methyl-6-(trifluoromethyl)nicotinamido)phenyl)nicotinate was hydrolyzed via Procedure M. 112 mg of 6-(2-chloro-5-(2-methyl-6-(trifluoromethyl)nicotinamido)phenyl)nicotinic acid was coupled to Methylamine Hydrochloride via Procedure G and purified by reverse phase HPLC to give pure N-(4-chloro-3-(5-(methylcarbamoyl)pyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide. MS (Q1) 449 (M)+.

Workup

  1. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-01066bcbc80d44a48ab84a32e282a826
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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