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HRID923021

反应详情

EQUATION

反应方程式

HRID 923021 的结构方程式

REACTANTS

反应物

2
结构：CS(N)(=O)=O
HCID72879

Methanesulfonamide

CH5NO2S

结构：O=C(Nc1ccc(Cl)c(-c2ccccn2)c1)c1ccc(Cl)nc1
HCID58614810

6-Chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]pyridine-3-carboxamide

C17H11Cl2N3O

PRODUCTS

生成物

1
结构：CS(=O)(=O)Nc1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)cn1
HCID58614869

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C
溶剂HCID3513851

BEMP phosphazene

C13H31N4P

PROCEDURE

实验过程

100 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)nicotinamide was reacted with methanesulfonamide and 108 μL of 2-tert-Butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine via Procedure F. The crude reaction was concentrated to dryness and purified by reverse phase HPLC to give pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(methylsulfonamido)nicotinamide. MS (Q1) 403 (M)+.

WORKUP

后处理

  1. customThe crude reaction
  2. concentrationwas concentrated to dryness
  3. custompurified by reverse phase HPLC