4-(2-Bromoethylsulfonyl)benzonitrile → 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile

HRID 923079Notes

Reaction equation

HRID 923079 reaction equation
Br[CH2:2][CH2:3][S:4]([C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH3:15][C:16]1[N:17]=[CH:18][NH:19][CH:20]=1>>[CH3:15][C:16]1[N:17]=[CH:18][N:19]([CH2:2][CH2:3][S:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)(=[O:6])=[O:5])[CH:20]=1

Participants

3

Reactant 2

HCID 668780144-(2-Bromoethylsulfonyl)benzonitrileHCID 178418800HCID 178418800, compound

Product 1

HCID 668960954-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile

Procedure

270 mg of 4-(2-bromoethylsulfonyl)benzonitrile was used in Procedure P with 4-methylimidazole to yield 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile. 320 mg of 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile was reacted via Procedure T to give 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzoic acid.

Sources & evidence

ORD record
ord-1305eb01f0b74b32be0e8013ee792b23
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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