4-Chloro-3-(pyridin-2-yl)aniline → HCID 58614916, compound

HRID 923082Notes

Reaction equation

HRID 923082 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[CH3:15][C:16]1[N:20]=[CH:19][N:18]([CH2:21][CH2:22][S:23]([C:26]2[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[N:17]=1>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:30](=[O:31])[C:29]2[CH:33]=[CH:34][C:26]([S:23]([CH2:22][CH2:21][N:18]3[CH:19]=[N:20][C:16]([CH3:15])=[N:17]3)(=[O:25])=[O:24])=[CH:27][CH:28]=2)=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 401519254-Chloro-3-(pyridin-2-yl)anilineHCID 66896466HCID 66896466, compound

Product 1

HCID 58614916HCID 58614916, compound

Procedure

60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2-(3-methyl-1H-1,2,4-triazole-1-yl)ethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-(3-methyl-1H-1,2,4-triazol-1-yl)ethylsulfonyl)benzamide. MS (Q1) 482.1 (M)+.

Workup

  1. customThe product was purified on reverse phase HPLC

Sources & evidence

ORD record
ord-d1f166d1883540918e0e7e13e858a872
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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