HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(+)-1-Aminopropan-2-ol → HCID 58614875, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(+)-1-Aminopropan-2-ol | HCID 7311736 | — |
| Reactant | 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide | HCID 58614798 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 58614875 | HCID 58614875 | — |
Reaction Steps
Procedure F was performed using 60 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide and 116 μL of S-(+)-1-amino-2-propanol in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield (S)—N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2-hydroxypropylamino)-2-methylnicotinamide. MS (Q1) 397.4 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278961B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-fd5d7f0e0e23445fb9ea3f182da67500 |
| Source note | uspto-grants-2016_03 |