6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide → HCID 178433153, compound

HRID 923145Notes

Reaction equation

HRID 923145 reaction equation
Cl[C:2]1[CH:23]=[CH:22][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[CH:10]=2)=[O:7])=[C:4]([CH3:24])[N:3]=1.[NH2:25][CH2:26][CH2:27][C:28]1[N:32]=[CH:31][NH:30][CH:29]=1>C(O)CCC>[NH:30]1[CH:29]=[C:28]([CH2:27][CH2:26][NH:25][C:2]2[CH:23]=[CH:22][C:5]([C:6]([NH:8][C:9]3[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)[CH:10]=3)=[O:7])=[C:4]([CH3:24])[N:3]=2)[N:32]=[CH:31]1

Participants

4

Reactant 2

HCID 586147986-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamideHCID 178419017HCID 178419017, compound

Product 1

HCID 178433153HCID 178433153, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Procedure F was performed using 60 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide and 93 mg of histamine in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield 6-(2-(1H-imidazol-4-yl)ethylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide. MS (Q1) 433.0 (M)

Workup

  1. customPurified by reverse phase HPLC

Sources & evidence

ORD record
ord-00f3bd887d6145b69e6bd0b478c50d44
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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