2-(Pyrrolidin-2-yl)ethan-1-amine → HCID 178512125, compound

HRID 923174Notes

Reaction equation

HRID 923174 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:21]=[CH:20][C:14]([C:15](=[NH:19])OCC)=[CH:13][CH:12]=2)=[O:10])=[CH:4][C:3]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1.[NH:28]1[CH2:32][CH2:31][CH2:30][CH:29]1[CH2:33][CH2:34][NH2:35]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:10])[C:11]2[CH:12]=[CH:13][C:14]([C:15](=[NH:19])[NH:35][CH2:34][CH2:33][CH:29]3[CH2:30][CH2:31][CH2:32][NH:28]3)=[CH:20][CH:21]=2)=[CH:4][C:3]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1

Participants

4

Reactant 2

HCID 140300092-(Pyrrolidin-2-yl)ethan-1-amineHCID 66877087HCID 66877087, compound

Product 1

HCID 178512125HCID 178512125, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 2-(pyrrolidin-2-yl)ethanamine (28 μl, 0.23 mmol) via procedure W to afford 90 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2-(pyrrolidin-2-yl)ethyl)carbamimidoyl)benzamide. MS (Q1) 448 (M)+.

Sources & evidence

ORD record
ord-81f3de94189241138fa1600f0947e55c
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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