Tetrahydrofurfurylamine → HCID 178512113, compound

HRID 923175Notes

Reaction equation

HRID 923175 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:21]=[CH:20][C:14]([C:15](=[NH:19])OCC)=[CH:13][CH:12]=2)=[O:10])=[CH:4][C:3]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1.[O:28]1[CH2:32][CH2:31][CH2:30][CH:29]1[CH2:33][NH2:34]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:10])[C:11]2[CH:12]=[CH:13][C:14]([C:15](=[NH:19])[NH:34][CH2:33][CH:29]3[CH2:30][CH2:31][CH2:32][O:28]3)=[CH:20][CH:21]=2)=[CH:4][C:3]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1

Participants

4

Reactant 2

HCID 253298TetrahydrofurfurylamineHCID 66877087HCID 66877087, compound

Product 1

HCID 178512113HCID 178512113, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with (tetrahydrofuran-2-yl)methanamine (23 μl, 0.23 mmol) via procedure W to afford 76 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-((tetrahydrofuran-2-yl)methyl)carbamimidoyl)benzamide. MS (Q1) 435 (M)+.

Sources & evidence

ORD record
ord-3a7bad2608914a038679d5614ce81187
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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