HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 3-Ethynylimidazo[1,2-b]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 3-((Trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazine | HCID 66735569 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Ethynylimidazo[1,2-b]pyridazine | HCID 46838760 | 94.4% |
Reaction Steps
To a solution of 3-((trimethylsilyl)ethynyl) imidazo[1,2-b]pyridazine (28.46 g, 0.132 mol) in 200 mL of THF was added 145 mL (0.145 mol) of tetrabutylammonium fluoride (1.0M in THF) at ambient temperature. The solution was stirred for 15 min, concentrated, and the crude product purified by silica gel flash chromatography (eluted with 0-5% MeOH/DCM) to provide 17.84 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278971B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-393ca1f9dc5844d5a2a56212986b8b24 |
| Source note | uspto-grants-2016_03 |