3-Ethynylimidazo[1,2-b]pyridazine → HCID 24826800, compound

HRID 923224Notes

Reaction equation

HRID 923224 reaction equation
[C:1]([C:3]1[N:7]2[N:8]=[CH:9][CH:10]=[CH:11][C:6]2=[N:5][CH:4]=1)#[CH:2].[Cl:12][C:13]1[CH:14]=[C:15]([NH:27][C:28](=[O:37])[C:29]2[CH:34]=[CH:33][C:32]([CH3:35])=[C:31](I)[CH:30]=2)[CH:16]=[CH:17][C:18]=1[CH2:19][N:20]1[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]1>>[Cl:12][C:13]1[CH:14]=[C:15]([NH:27][C:28](=[O:37])[C:29]2[CH:34]=[CH:33][C:32]([CH3:35])=[C:31]([C:2]#[C:1][C:3]3[N:7]4[N:8]=[CH:9][CH:10]=[CH:11][C:6]4=[N:5][CH:4]=3)[CH:30]=2)[CH:16]=[CH:17][C:18]=1[CH2:19][N:20]1[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 468387603-Ethynylimidazo[1,2-b]pyridazineHCID 66736590HCID 66736590, compound

Product 1

HCID 24826800HCID 24826800, compound

Procedure

The title compound was synthesized according to Example 14, from 3-ethynylimidazo[1,2-b]pyridazine and N-(3-chloro-4-((4-methylpiperazin-1-yl)methyl)phenyl)-3-iodo-4-methylbenzamide. The product was obtained as a solid: 499 m/z (M+H).

Workup

  1. customThe product was obtained as a solid

Sources & evidence

ORD record
ord-8976703bad9440f1937874bec0585a9f
Source dataset
uspto-grants-2016_03
Patent number
US09278971B2

Reaction notes

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