反应详情

温度

90 °C

To 1-(1-trityl-1H-imidazol-4-yl)ethanol (8.06 g, 22.7 mmol) in dioxane (400 mL) is added manganese dioxide (9.9 g, 113.8 mmol). The reaction mixture is heated to 90° C. and stirred for 18 h. The reaction is allowed to cool to room temperature and filtered through diatomaceous earth. The filtered solvent is removed in vacuo to yield the product. MS (ESI) m/z 353 (M+H) (prepared similarly in Bioorg. Med. Chem. 2004, 12(9), 2251.)

1. temperatureto cool to room temperature
2. filtrationfiltered through diatomaceous earth
3. customThe filtered solvent is removed in vacuo
4. customto yield the product
5. customMS (ESI) m/z 353 (M+H) (prepared similarly in Bioorg