反应详情

To a solution of SOCl2 (0.55 mL, 7.54 mmol) in CH2Cl2 (15 mL) at 0° C. is added 3-[3-(2-bromobenzyl)-3H-imidazol-4-yl]propan-1-ol in portion and the resulting white suspension is refluxed for 1.5 h. The mixture is cooled with ice and collected to give a buff-colored solid, which is partitioned between CH2Cl2 and saturated aqueous NaHCO3. The organic layer is washed with brine, dried over anhydrous Na2SO4, and concentrated to give an oil. MS (ESI) m/z 313 (M+H).

1. temperaturethe resulting white suspension is refluxed for 1.5 h
2. temperatureThe mixture is cooled with ice
3. customcollected
4. customto give a buff-colored solid, which
5. customis partitioned between CH2Cl2 and saturated aqueous NaHCO3
6. washThe organic layer is washed with brine
7. dry with materialdried over anhydrous Na2SO4
8. concentrationconcentrated
9. customto give an oil