Methylamine ethanol → HCID 178485598, compound

HRID 923321Notes

Reaction equation

[NH2:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9]C)=O)[N:3]=1.C(O)C.[CH3:14][NH2:15]>>[NH2:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH:15][CH3:14])=[O:9])[N:3]=1

Participants

Reactant 2

HCID 22028356Methylamine ethanol

HCID 178499187HCID 178499187, compound

Product 1

HCID 178485598HCID 178485598, compoundYield 63%

Conditions

Temperature: 80 °C

Procedure

A mixture of methyl 5-amino-1H-1,2,4-triazole-3-carboxylate (800 mg, 5.63 mmol) and methylamine ethanol solution (30%, 10 ml) was stirred for 3 h at 80° C. The resulting mixture was concentrated under vacuum to afford 5-amino-N-methyl-1H-1,2,4-triazole-3-carboxamide as a white solid (0.5 g, 63%).

Workup

concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record: ord-a513905c50134948be06ff6d9e1b3920
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278973B2

Reaction notes

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