反应详情

温度

110 °C

A mixture of 5-benzyl-2H-1,2,4-triazol-3-amine (174 mg, 1.00 mmol, 1.00 equiv), acetic acid (3 mL), and ethyl 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-oxopropanoate (275 mg, 1.10 mmol, 1.10 equiv) was stirred overnight at 110° C. The reaction was concentrated to dryness and purified with prep-TLC (MeOH:DCM=1:30) to afford 30.7 mg (8%) of 2-benzyl-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,2,4]triazolo[1,5-α]pyrimidin-7(4H)-one as a yellow solid.

1. concentrationThe reaction was concentrated to dryness
2. custompurified with prep-TLC (MeOH:DCM=1:30)