HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-(Methoxymethyl)pyridine-2,3-dicarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 46899675 | HCID 46899675 | — |
| Product | 5-(Methoxymethyl)pyridine-2,3-dicarboxylic acid | HCID 10998311 | — |
Reaction Steps
7.0 g (35 mmol) 5-chloromethyl-2,3-pyridinedicarboxylic acid anhydride were dissolved in 165 g (5.16 mol) methanol at room temperature, causing formation of monoesters. 14 g (350 mmol) NaOH (50% in water) were slowly added whereupon the temperature rose to 50° C. and carboxylate started to precipitate. Stirring was continued for additional 5 hrs at 65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278977B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c57cf6fd58c74b67bf71faf6a85ee8d8 |
| Source note | uspto-grants-2016_03 |