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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 923401Generated: October 30, 2026

Trifluoroacetic acid → (S)-3,3-dimethyl-2-(((S)-tetrahydrofuran-3-yloxy)carbonylamino)butanoic acid

https://huagongshe.com/reaction/923401

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant(S)-tert-butyl 3,3-dimethyl-2-(((S)-tetrahydrofuran-3-yloxy)carbonylamino)butanoateHCID 59540266—
SolventDichloromethaneHCID 6344—
Product(S)-3,3-dimethyl-2-(((S)-tetrahydrofuran-3-yloxy)carbonylamino)butanoic acidHCID 58938768—

Reaction Steps

To a solution of the product from Example 59A (0.037 g, 0.123 mmol) in dichloromethane (1.2 mL) was added trifluoroacetic acid (1.2 mL) and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated to give the title compound which was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09278922B2
Source datasetuspto-grants-2016_03
ORD IDord-79bb69b42a1c4c17930a23e54da0c44c
Source noteuspto-grants-2016_03