HCID 59166512, compound → HCID 178502345, compound

HRID 923418Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([NH:31][C:32]([C@H:34]3[CH2:38][CH2:37][CH2:36][N:35]3[C:39]([O:41][CH2:42][CH:43]3[C:55]4[CH:54]=[CH:53][CH:52]=[CH:51][C:50]=4[C:49]4[C:44]3=[CH:45][CH:46]=[CH:47][CH:48]=4)=[O:40])=[O:33])=[CH:27][CH:26]=2)[CH2:9][C:10]2[CH:23]=[CH:22][C:13]3[NH:14][C:15]([C@@H:17]4[CH2:21][CH2:20][CH2:19][NH:18]4)=[N:16][C:12]=3[CH:11]=2)=[CH:4][CH:3]=1.[OH:56][C:57]([CH3:68])([CH3:67])[C@H:58]([NH:62][C:63]([O:65][CH3:66])=[O:64])[C:59](O)=[O:60]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:24][C:25]2[CH:26]=[CH:27][C:28]([NH:31][C:32]([C@H:34]3[CH2:38][CH2:37][CH2:36][N:35]3[C:39]([O:41][CH2:42][CH:43]3[C:44]4[CH:45]=[CH:46][CH:47]=[CH:48][C:49]=4[C:50]4[C:55]3=[CH:54][CH:53]=[CH:52][CH:51]=4)=[O:40])=[O:33])=[CH:29][CH:30]=2)[CH2:9][C:10]2[CH:23]=[CH:22][C:13]3[NH:14][C:15]([C@@H:17]4[CH2:21][CH2:20][CH2:19][N:18]4[C:59](=[O:60])[C@@H:58]([NH:62][C:63]([O:65][CH3:66])=[O:64])[C:57]([OH:56])([CH3:68])[CH3:67])=[N:16][C:12]=3[CH:11]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 59166512HCID 59166512, compound

HCID 178522119HCID 178522119, compound

Product 1

HCID 178502345HCID 178502345, compoundYield 101.3%

Procedure

The product from Example 99F (0.092 g, 0.125 mmol), (S)-3-hydroxy-2-(methoxycarbonylamino)-3-methylbutanoic acid (0.029 g, 0.15 mmol) was processed as in Example 99E to give 0.115 g (100%) of the title compound.

Sources & evidence

ORD record: ord-782f73ce2e1c4ee093210a1418140425
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278922B2

Reaction notes

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