HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphite → Methyl 4-(diethoxyphosphorylmethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| Product | Methyl 4-(diethoxyphosphorylmethyl)benzoate | HCID 10946061 | — |
Reaction Steps
A solution of methyl 4-(bromomethyl)benzoate (12.5 g, 54.6 mmol) in triethyl phosphite (20 mL, 114 mmol) was heated at 150° C. for 2 hours. After cooling, the solution was concentrated under vacuum. Purification by chromatography (silica gel, 0-2% methanol in dichloromethane) afforded the title compound. MS (ESI) m/z 287 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278922B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c73feee6c93d4203b8e2798f0c973d87 |
| Source note | uspto-grants-2016_03 |