1,4-Dioxane hydrochloride → HCID 118308713, compound

HRID 923462Notes

Reaction equation

HRID 923462 reaction equation
[OH:1][CH2:2][C@H:3]([NH:10]C(=O)OC(C)(C)C)[C:4]1[N:5]=[N:6][N:7]([CH3:9])[N:8]=1.[ClH:18].O1CCOCC1>CO>[ClH:18].[NH2:10][C@H:3]([C:4]1[N:5]=[N:6][N:7]([CH3:9])[N:8]=1)[CH2:2][OH:1]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 118318071HCID 118318071, compound

Product 1

HCID 118308713HCID 118308713, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 106 mg of tert-butyl [(1R)-2-hydroxy-1-(2-methyl-2H-tetrazol-5-yl)ethyl]carbamate in 3 ml of methanol was added to 1.5 ml of a 4 M hydrogen chloride/1,4-dioxane solution, followed by stirring at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure to obtain 78 mg of (2R)-2-amino-2-(2-methyl-2H-tetrazol-5-yl)ethanol hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-be943e9a7a894c8488323bc1fdc1a3b7
Source dataset
uspto-grants-2016_03
Patent number
US09278968B2

Reaction notes

Loading…