Water → HCID 118308754, compound

Participants

Reaction Steps

To a mixture of 4 mg of lithium aluminum hydride and 0.2 ml of THF was added dropwise a solution of 20 mg of ethyl 2-amino-2-(pyrimidin-2-yl)propanoate in 0.2 ml of THF at 0° C. solution, followed by stirring at the same temperature for 7 hours. 2.5 mg of lithium aluminum hydride was added thereto, followed by stirring at 0° C. for 1 hour. 32 μl of water, 32 μl of a 15% aqueous sodium hydroxide solution, and 96 μl of water were sequentially added thereto at 0° C. The insoluble materials of the reaction mixture were filtered over Celite and washed with ethyl acetate, and the filtrate was then concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 7 mg of 2-amino-2-(pyrimidin-2-yl)propan-1-ol.

Provenance & Evidence