Water → HCID 118308682, compound

Participants

Reaction Steps

To a mixture of 1.7 g of 2,2,2-trifluoro-N-(2-vinylbenzyl)acetamide, 1.31 g of 4-methylmorpholine 4-oxide, 43 ml of THF, and 17 ml of water was added 1.85 ml of a 2.5% aqueous tetraoxoosmium solution, followed by stirring at room temperature for 16 hours. To the reaction mixture was added a 10% aqueous sodium thiosulfate solution, followed by stirring at room temperature, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution and washed with anhydrous magnesium sulfate, and the solvent was then evaporated under reduced pressure to obtain 1.94 g of N-[2-(1,2-dihydroxyethyl)benzyl]-2,2,2-trifluoroacetamide.

Provenance & Evidence