Triacetoxyperiodinane → HCID 89253130, compound

Participants

Reaction Steps

Prepared from compound 87: To a stirring solution of 4-((N-(4-hydroxybutyl)-4-methoxybenzamido)methyl)phenyl 4-(heptyloxy)benzoate 87 (258 mg, 0.484 mmol) in DCM was added sodium bicarbonate (81 mg, 0.968 mmol) and Dess-Martin periodinane (308 mg, 0.726 mmol). The reaction mixture was stirred at room temperature for 2 h. The crude reaction was diluted with EA followed by NaHCO3 and aq. NaS2O3. The biphasic mixture was stirred overnight at room temperature. The organic phase was separated, washed with NaHCO3, dried over MgSO4, and concentrated to yield 264 mg of crude 4-((4-methoxy-N-(4-oxobutyl)benzamido)methyl)phenyl 4-(heptyloxy)benzoate INT-8. LCMS-ESI (m/z) calculated for C33H39NO6: 545; found 546 [M+H]+, tR=3.14 min (Method 3).

Provenance & Evidence