HCID 67951109, compound → HCID 3441859, compound

Participants

Reaction Conditions

Reaction Steps

Ester 7 (160 mg, 0.63 mmol) was suspended in conc. HCl (4 mL) and heated with stirring at 100° C. for 5 h until hydrolysis completed. The mixture was cooled to room temperature, diluted with water (500 mL), and the precipitate was collected to give the title compound (151 mg, 100% yield). C10H10N2O3S; white solid; mp 355° C. (decomposed); 1H NMR (400 MHz, CD3OD) δ 7.13 (1H, s), 4.60 (2H, s), 2.71 (3H, s), 2.59 (3H, s); 13C NMR (100 MHz, CD3OD) δ 170.2, 165.7, 164.2, 163.3, 151.3, 123.3, 115.1, 45.2, 24.7, 17.9; ESI-HRMS (negative mode) calcd for C10H9N2O3S: 237.0334. found: m/z 237.0329 [M−H]−.

Provenance & Evidence