HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 923665Generated: October 31, 2026
Phenylacetylene → HCID 117915868, compound
https://huagongshe.com/reaction/923665
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenylacetylene | HCID 10821 | — |
| Reactant | HCID 117903200 | HCID 117903200 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 117915868 | HCID 117915868 | — |
Reaction Steps
Dichlorobis(triphenylphosphine)palladium(II) (17 mg, 25 μmol) is added to a mixture of 2-amino-4,6-dibromo-5-methoxy-pyridine A1 (70 mg, 0.25 mmol), ethynylbenzene (55 μl, 0.50 mmol), copper(I) iodide (5 mg, 25 μmol) triethylamine (140 μl,1 mmol) and THF (1 ml) under argon atmosphere and is stirred at 50° C. for 1 h. The mixture is concentrated in vacuo and the product purified by RP HPLC. Yield: 35 mg (47%). HPLC-MS: tR=1.21 min (METHOD—1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09278978B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-5118fa3e9ecc4b3b9173480d5b25c0d2 |
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| Source note | uspto-grants-2016_03 |
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